Publications | Hypo-RESOLVE

2024

Joseph Mellor, Dmitry Kuznetsov, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Stephanie A. Amiel, Mark Ibberson, Stuart McGurnaghan, Luke Blackbourn, William Berthon, Adel Salem, Yongming Qu, Rory J. McCrimmon, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Joanna Leaviss, Paul M. McKeigue & Helen M. Colhoun
Estimating risk of consequences following hypoglycaemia exposure using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
Diabetologia 67, 2210–2224 (2024). https://doi.org/10.1007/s00125-024-06225-1
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Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Petra Martina Baumann, Zeinab Mahmoudi, Gilberte Martine-Edith, Julia K. Mader, Monika Cigler, Julie Maria Bøggild Brøsen, Allan Vaag, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J. McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Evertine Abbink, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary & Frans Pouwer on behalf of the Hypo-RESOLVE consortium
The impact of hypoglycaemia on daily functioning among adults with diabetes: a prospective observational study using the Hypo-METRICS app
Diabetologia 67, 2160–2174 (2024). https://doi.org/10.1007/s00125-024-06233-1
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Joseph Mellor, Dmitry Kuznetsov, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Stephanie A. Amiel, Mark Ibberson, Stuart McGurnaghan, Luke Blackbourn, William Berthon, Adel Salem, Yongming Qu, Rory J. McCrimmon, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Joanna Leaviss, Paul M. McKeigue & Helen M. Colhoun
Risk factors and prediction of hypoglycaemia using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
Diabetologia 67, 1588–1601 (2024). https://doi.org/10.1007/s00125-024-06177-6
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Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan, the Hypo-RESOLVE consortium
The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode
Cardiovasc Diabetol 23, 55 (2024). https://doi.org/10.1186/s12933-023-02095-w
Therese W. Fabricius, Clementine E. M. Verhulst, Peter L. Kristensen, Jens J. Holst, Cees J. Tack, Rory J. McCrimmon, Simon R. Heller, Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard on behalf of the Hypo-RESOLVE consortium
Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study
Acta Diabetologica (2024) 61:623–633. https://doi.org/10.1007/s00592-024-02239-8
Chiara Roversi, Nunzio Camerlingo, Martina Vettoretti, Andrea Facchinetti, Pratik Choudhary, Giovanni Sparacino, Simone Del Favero, Hypo-RESOLVE Consortium
Risk of Hypoglycemia in Type 1 Diabetes Management: an In-Silico Sensitivity Analysis to Assess and Rank the Quantitative Impact of Different Behavioral Factors
Computer Methods and Programs in Biomedicine 244 (2024) 107943. htpps://doi.org/10.1016/j.cmpb.2023.107943
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2023

Clementine E. M. Verhulst MD, Julia I. P. van Heck MSc, Therese W. Fabricius MD, Rinke Stienstra PhD, Steven Teerenstra PhD, Rory J. McCrimmon PhD, Cees J. Tack PhD, Ulrik Pedersen-Bjergaard PhD, Bastiaan E. de Galan PhD, on behalf of the Hypo-RESOLVE consortium
Hypoglycaemia induces a sustained pro-inflammatory response in people with type 1 diabetes and healthy controls
Diabetes Obes Metab.2023;25:3114–3124. https://doi.org/10.1111/dom.15205
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Clementine E.M. Verhulst; Therese W. Fabricius; Giesje Nefs; Roy P.C. Kessels; Frans Pouwer; Steven Teerenstra; Cees J. Tack; Melanie M. Broadley; Peter L. Kristensen; Rory J. McCrimmon; Simon Heller; Mark L. Evans; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan, on behalf of the Hypo-RESOLVE consortium
Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes
Diabetes Care 2022;45(9):2103–2110. https://doi.org/10.2337/dc21-2502
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Uffe Søholm; Natalie Zaremba; Melanie Broadley; Johanne Lundager Axelsen; Patrick Divilly; Gilberte Martine-Edith; Stephanie A Amiel; Julia K Mader; Ulrik Pedersen-Bjergaard; Rory J McCrimmon; Eric Renard; Mark Evans; Bastiaan de Galan; Simon Heller; Christel Hendrieckx; Pratik Choudhary; Jane Speight; Frans Pouwer; Hypo-RESOLVE consortium Hypo-RESOLVE consortium
Assessing the Content Validity, Acceptability, and Feasibility of the Hypo-METRICS App: Survey and Interview Study
JMIR Diabetes, 2023;8:e42100. https://doi.org/10.2196/42100
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Uffe Søholm, Elizabeth Holmes-Truscott, Melanie Broadley, Stephanie A Amiel, Christel Hendrieckx, Pratik Choudhary, Frans Pouwer, James A M Shaw, Jane Speight
Hypoglycaemia symptom frequency, severity, burden, and utility among adults with type 1 diabetes and impaired awareness of hypoglycaemia: Baseline and 24-week findings from the HypoCOMPaSS study
Diabetic Medicine, 2023 Sep 25:e15231. https://doi.org/10.1111/dme.15231
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Alison D. McNeilly, Jennifer R. Gallagher, Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Albena T. Dinkova-Kostova, Jeffrey-T. Huang, Michael L. J. Ashford & Rory J. McCrimmon on behalf of the Hypo-RESOLVE Consortium
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
Diabetologia 66, 1340–1352 (2023). https://doi.org/10.1007/s00125-023-05907-6
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Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
EMBO Reports (2023)e57344. https://doi.org/10.15252/embr.202357344
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Uffe Søholm , Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Jill Carlton, Julia K. Mader, Petra Martina Baumann, Mikel Gomes, Gilberte Martine-Edith, Daniel J. Pollard, Dajana Rath, Simon Heller, Ulrik Pedersen-Bjergaard, Rory J. McCrimmon, Eric Renard, Mark Evans, Bastiaan de Galan, Thomas Forkmann, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer, on behalf of the Hypo-RESOLVE consortium
Psychometric properties of an innovative smartphone application to investigate the daily impact of hypoglycemia in people with type 1 or type 2 diabetes: The Hypo-METRICS app
PLoS ONE 18(3): e0283148. https://doi.org/10.1371/journal.pone.0283148
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2022

Clementine E M Verhulst, Therese W Fabricius, Steven Teerenstra, Peter L Kristensen, Cees J Tack, Rory J McCrimmon, Simon Heller, Mark L Evans, Stephanie A Amiel, Ulrik Pedersen-Bjergaard, Bastiaan E de Galan; Hypo-RESOLVE consortium
Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review
Diabetologia. 2022 Oct;65(10):1601-1612. doi: 10.1007/s00125-022-05749-8. Epub 2022 Jul 22.
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Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J. Child, Jonathan Comins, Rory J. McCrimmon, Bastiaan de Galan, John Brazier, Hypo-RESOLVE CONSORTIUM
Producing a preference-based quality of LIFE measure to quantify the impact of HYPOGLYCAEMIA on people living with diabetes: A mixed-methods research protocol
Diabetic Medicine. 2023;40:e15007. https://doi.org/10.1111/dme.15007
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Clementine E.M. Verhulst; Julia I.P. van Heck; Therese W. Fabricius; Rinke Stienstra; Steven Teerenstra; Rory J. McCrimmon; Cees J. Tack; Ulrik Pedersen-Bjergaard; Bastiaan E. de Galan, on behalf of the Hypo-RESOLVE consortium
Sustained Proinflammatory Effects of Hypoglycemia in People With Type 2 Diabetes and in People Without Diabetes
Diabetes 2022;71(12):2716–2727. https://doi.org/10.2337/db22-0246
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Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P. Berney, David Tarussio, Maxime Jan & Bernard Thorens
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
Nature Communications | (2022)13:5761. https://doi.org/10.1038/s41467-022-33484-6
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Melanie Broadley, Hannah Chatwin, Uffe Søholm, Stephanie A Amiel, Jill Carlton, Bastiaan E De Galan, Christel Hendrieckx, Rory J McCrimmon, Søren E Skovlund, Frans Pouwer, Jane Speight, on behalf of the Hypo-RESOLVE Consortium
The 12-Item Hypoglycemia Impact Profile (HIP12): psychometric validation of a brief measure of the impact of hypoglycemia on quality of life among adults with type 1 or type 2 diabetes
BMJ Open Diab Res Care 2022;10:e002890. doi:10.1136/ bmjdrc-2022-002890
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Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan de Galan, Rory J. McCrimmon, Ulrik Pedersen-Bjergaard, FransP ouwer, Jane Speight, On behalf of the Hypo-RESOLVE Consortium
The impact of hypoglycaemia on quality of life among adults with type 1 diabetes: Results from “YourSAY: Hypoglycaemia”
Journal of Diabetes and its Complications, Volume 36, Issue 7, 21 June 2022, 108232. https://doi.org/10.1016/j.jdiacomp.2022.108232
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Emily O.Staricoff, Mark L.Evans
Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia
Current Opinion in Endocrine and Metabolic Research, Volume 24, 2022, 100353. https://doi.org/10.1016/j.coemr.2022.100353
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Patrick Divilly, Natalie Zaremba, Zeinab Mahmoudi, Uffe Søholm, Daniel J. Pollard, Melanie Broadley, Evertine J. Abbink, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Eric Renard, Mark Evans, Jane Speight, Alan Brennan, Rory J. McCrimmon, Matthias Müllenborn, Simon Heller, Alexander Seibold, Julia K. Mader, Stephanie A. Amiel, Frans Pouwer, Pratik Choudhary, Hypo-RESOLVE Consortium
Hypo-METRICS: Hypoglycaemia—MEasurement, ThResholds and ImpaCtS—A multi-country clinical study to define the optimal threshold and duration of sensor-detected hypoglycaemia that impact the experience of hypoglycaemia, quality of life and health economic outcomes: The study protocol
Diabetic Medicine. 2022;00:e14892. https://doi.org/10.1111/dme.14892
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Nunzio Camerlingo, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Pratik Choudhary, Giovanni Sparacino, on behalf of the Hypo-RESOLVE Consortium
Generation of post-meal insulin correction boluses in type 1 diabetes simulation models for in-silico clinical trials: More realistic scenarios obtained using a decision tree approach
Comput. Methods Programs Biomed., 221(6): 106862, 2022. https://doi.org/10.1016/j.cmpb.2022.106862
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Uffe Søholm, Melanie Broadley, Natalie Zaremba, Patrick Divilly, Giesje Nefs, Zeinab Mahmoudi, Bastiaan de Galan, Ulrik Pedersen-Bjergaard, Alan Brennan, Daniel John Pollard, Rory J McCrimmon, Stephanie A. Amiel, Christel Hendrieckx, Jane Speight, Pratik Choudhary, Frans Pouwer
Investigating the day-to-day impact of hypoglycaemia in adults with type 1 or type 2 diabetes: design and validation protocol of the Hypo-METRICS application
BMJ Open 2022;12:e051651. https://doi.org/10.1136/bmjopen-2021-051651
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Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Hannah Chatwin, Alison Scope, Anna Cantrell, Simon Heller, Bastiaan E. de Galan, Christel Hendrieckx, Frans Pouwer, on behalf of the Hypo-RESOLVE consortium
The impact of hypoglycaemia in children and adolescents with type 1 diabetes on parental quality of life and related outcomes: A systematic review
Pediatrics Diabetes, Volume23, Issue3, 2022. https://10.1111/pedi.13308
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Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens
Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
Molecular Metabolism, Volume 61, July 2022, 101479. https://doi.org/10.1016/j.molmet.2022.101479
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2021

Heather J Merchant and Alison D McNeilly
Hypoglycaemia: Still the main drawback of insulin 100 years on : "From man to mouse"
Diabetic Medicine, 2021 Dec;38(12):e14721. https://doi.org/10.1111/dme.14721
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Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, on behalf of the Hypo-RESOLVE Consortium
Choosing the duration of continuous glucose monitoring for reliable assessment of time in range: A new analytical approach to overcome the limitations of correlation-based methods
Diabet Med. 2021, Dec. 4th; 00:e14758; https://doi:10.1111/dme.14758
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Manon Coolen, Melanie Broadley, Christel Hendriecks, Hannah Chatwin, Mark Clowes, Simon Heller, Bastiaan E. de Galan, Jane Speight, Frans Pouwer, for the Hypo-RESOLVE Consortium¶
The impact of hypoglycemia on quality of life and related outcomes in children and adolescents with type 1 diabetes: A systematic review
PLOS ONE, December 2, 2021. https://doi.org/10.1371/journal.pone.0260896
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Hannah Chatwin, Melanie Broadley, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie A. Amiel, Bastiaan E. de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer, the Hypo-RESOLVE Consortium
Unmet support needs relating to hypoglycaemia among adults with type 1 diabetes: Results of a multi-country web-based qualitative study
Diabetic Medicine. 2021;00:e14727. https://doi.org/10.1111/dme.14727
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Zeinab Mahmoudia, Simone Del Favero, PeterJacob, Pratik Choudhary, on behalf of the Hypo-RESOLVE Consortium
Toward an Optimal Definition of Hypoglycemia with Continuous Glucose Monitoring
Computer Methods and Programs in Biomedicine, Volume 209, September 2021, e106303. https://doi.org/10.1016/j.cmpb.2021.106303
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Kevin A. Matlock, Melanie Broadley, Christel Hendrieckx, Mark Clowes, Anthea Sutton, Simon R. Heller, Bastiaan E. de Galan, Frans Pouwer, Jane Speight, for the Hypo-RESOLVE consortium,
Changes in quality of life following hypoglycaemia in adults with type 2 diabetes: A systematic review of longitudinal studies
Diabetic Medicine. 2021;00:e14706. https://doi.org/10.1111/dme.14706
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Hannah Chatwin, Melanie Broadley, Mette Valdersdorf Jensen, Christel Hendrieckx, Jill Carlton, Simon Heller, Stephanie Amiel, Bastiaan de Galan, Norbert Hermanns, Katharina Finke-Groene, Jane Speight, Frans Pouwer
‘Never again will I be carefree’: a qualitative study of the impact of hypoglycemia on quality of life among adults with type 1 diabetes
BMJ Open Diab Res Care 2021 Aug; 9:e002322. https://doi.org/10.1136/bmjdrc-2021-002322
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Mette Valdersdorf Jensen, Melanie Broadley, Jane Speight, Alison Scope, Louise Preston, Simon Heller, Bastiaan E. de Galan, Frans Pouwer, Christel Hendrieckx, the Hypo-RESOLVE Consortium
The impact of hypoglycaemia on the quality of life of family members of adults with type 1 or type 2 diabetes: A qualitative systematic review
Diabet Med, e14666, July 2021. https.//doi.org/doi:10.1111/dme.14666.
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Nunzio Camerlingo, Martina Vettoretti, Giovanni Sparacino, Andrea Facchinetti, Julia K. Mader, Pratik Choudhary, Simone Del Favero, on behalf of the Hypo-RESOLVE Consortium
Design of clinical trials to assess diabetes treatment: minimum duration of continuous glucose monitoring data to estimate time-in-ranges with the desired precision
Diabetes Obes. Metab., 2021, July, 1st. https://doi.org/10.1111/dom.14483
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C. Roversi, M. Vettoretti, S. Del Favero, A. Facchinetti, P. Choudhary, G. Sparacino
Impact of Carbohydrate Counting Error on Glycemic Control in Open-Loop Management of Type 1 Diabetes: Quantitative Assessment Through an in silico Trial
J Diabetes Sci Technol, 2021 May 12; https://doi.org/10.1177/19322968211012392
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Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenaël Labouebe and Bernard Thorens.
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
Diabetes 2021;70(7):1443–1457. https://doi.org/10.2337/db20-1121
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Hannah Chatwin, Melanie Broadley, Jane Speight, Anna Cantrell, Anthea Sutton, Simon Heller, Bastiaan de Galan, Christel Hendrieckx, Frans Pouwer; For the Hypo-RESOLVE Consortium
The Impact of Hypoglycaemia on Quality of Life Outcomes Among Adults with Type 1 Diabetes: A Systematic Review
Diabetes Research and Clinical Practice, Volume 174, 108752, April 01, 2021. https://doi.org/10.1016/j.diabres.2021.108752
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Keeran Vickneson; Jessica Blackburn; Jennifer R. Gallagher; Mark L. Evans, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, Bernard Thorens, Alison D. McNeilly, Rory J. McCrimmon
Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.
Diabetologia volume 64, pages 1436–1441 (2021). https://doi.org/10.1007/s00125-021-05425-3
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Carlton J, Leaviss J, Pouwer F, Hendreickx C, Broadley MM, Clowes M, McCrimmon RJ, Heller SR, Speight J
The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods.
Diabetologia 64, 1213–1225 (2021). https://doi.org/10.1007/s00125-021-05382-x.
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Omar Diouri, Monika Cigler, Martina Vettoretti, Julia K. Mader, Pratik Choudhary, Eric Renard, HYPO‐RESOLVE Consortium
Hypoglycaemia detection and prediction techniques: A systematic review on the latest developments
DiabetesMetab Res Rev. 2021;e344. https://doi.org/10.1002/dmrr.3449
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Therese W. Fabricius, Clementine E.M. Verhulst, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Thomas R. Pieber, Bastiaan E. de Galan, Ulrik Pedersen-Bjergaard, on behalf of the Hypo-RESOLVE consortium
Hyperinsulinaemic-hypoglycaemic glucose clamps in human research – a systematic review of the literature and a proposal of a standardized protocol
Diabetologia (2021). https://doi.org/10.1007/s00125-020-05361-8
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2020

Simon Quenneville; Gwenaël Labouèbe; Davide Basco; Salima Metref; Benoit Viollet; Marc Foretz; Bernard Thorens
Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation
Diabetes 2020;69(11):2253–2266
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Camerlingo N, Vettoretti M, Del Favero S, Facchinetti A, Sparacino G.
Mathematical Models of Meal Amount and Timing Variability With Implementation in the Type-1 Diabetes Patient Decision Simulator
J Diabetes Sci Technol., 2020 Sep 17:1932296820952123, doi: 10.1177/1932296820952123
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Suresh Rama Chandran, Peter Jacob, Pratik Choudhary
Baseline Glucose Variability and Interweek Variability Affects the Time to Stability of Continuous Glucose Monitoring-Derived Glycemic Indices
Diabetes Technology & Therapeutics, doi: 10.1089/dia.2020.0011
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Camerlingo N, Vettoretti M, Facchinetti A, Sparacino G, Mader JK, Choudhary P, Del Favero S.
An analytical approach to determine the optimal duration of continuous glucose monitoring data required to reliably estimate time in hypoglycemia.
Sci Rep. 2020 Oct 23;10(1):18180. doi: 10.1038/s41598-020-75079-5.
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Chiara Roversi, Martina Vettoretti, Simone Del Favero, Andrea Facchinetti, Giovanni Sparacino
Modeling carbohydrate counting error in type 1 diabetes management
Diabetes Technology & Therapeutics, doi: 10.1089/dia.2019.0502
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Othmar Moser, Haris Ziko, Hesham Elsayed, Daniel Hochfellner, Tina Pöttler, Alexander Mueller, Max L Eckstein, Harald Sourij, Julia K Mader, on behalf of the Hypo-RESOLVE Consortium
People with type 1 diabetes and impaired awareness of hypoglycaemia have a delayed reaction to perform a glucose scan during hypoglycaemia – a prospective observational study
Diabetic Medicine, Volume37, Issue12
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de Galan BE, McCrimmon R, Ibberson M, Heller SR, Choudhary P, Pouwer F, Speight J, Carlton J, Pieber TR, Rosilio M, Tack CJ, Müllenborn M; Hypo-RESOLVE Consortium
Reducing the Burden of Hypoglycaemia in People with Diabetes through Increased Understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo-RESOLVE) study
Diabetic Medicine, Vol. 37, Issue6 June 2020, pp. 1066-1073.doi: 10.1111/dme.14240
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